Peter C K Leung Selected Research

Gonadotropin-Releasing Hormone (GnRH)

1/2018	Increased AIF-1-mediated TNF-α expression during implantation phase in IVF cycles with GnRH antagonist protocol.
1/2016	Gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor are expressed at tubal ectopic pregnancy implantation sites.
1/2013	Overexpression of wild-type but not C134W mutant FOXL2 enhances GnRH-induced cell apoptosis by increasing GnRH receptor expression in human granulosa cell tumors.
1/2013	Targeting gonadotropin-releasing hormone receptor inhibits the early step of ovarian cancer metastasis by modulating tumor-mesothelial adhesion.
3/2011	Gonadotropin-releasing hormone-II increases membrane type I metalloproteinase production via beta-catenin signaling in ovarian cancer cells.
8/2009	Gonadotropin-releasing hormone (GnRH)-I and GnRH-II induce cell growth inhibition in human endometrial cancer cells: involvement of integrin beta3 and focal adhesion kinase.
5/2009	Gonadotropin-releasing hormone type II induces apoptosis of human endometrial cancer cells by activating GADD45alpha.
5/2009	GnRH signaling in intrauterine tissues.
11/2008	Gonadotropin-releasing hormone and ovarian cancer: a functional and mechanistic overview.
11/2008	Transcripts of testicular gonadotropin-releasing hormone, steroidogenic enzymes, and intratesticular testosterone levels in infertile men.

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Peter C K Leung Research Topics

Disease

58	Ovarian Neoplasms (Ovarian Cancer) 01/2023 - 05/2002
50	Neoplasms (Cancer) 01/2022 - 03/2003
12	Endometrial Neoplasms (Endometrial Cancer) 10/2019 - 06/2004
12	Carcinoma (Carcinomatosis) 01/2015 - 10/2005
10	Ovarian Epithelial Carcinoma 02/2015 - 10/2003
7	Pre-Eclampsia (Preeclampsia) 01/2023 - 10/2004
7	Neoplasm Metastasis (Metastasis) 10/2015 - 04/2006
6	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 11/2023 - 08/2012
6	Breast Neoplasms (Breast Cancer) 01/2020 - 08/2003
4	Choriocarcinoma 05/2019 - 07/2002
4	Carcinogenesis 07/2010 - 01/2003
3	Infertility (Sterility) 11/2023 - 12/2016
3	Endometriosis 10/2020 - 09/2011
3	Ovarian Hyperstimulation Syndrome 01/2020 - 02/2003
3	Granulosa Cell Tumor 01/2014 - 01/2013
2	Body Weight (Weight, Body) 11/2021 - 07/2004
2	Disease Progression 10/2020 - 07/2018
2	Pathologic Processes 01/2020 - 06/2016
2	Insulin Resistance 06/2019 - 01/2019
2	Obesity 01/2019 - 10/2009
2	Inflammation (Inflammations) 01/2018 - 08/2006
2	Hyperandrogenism 02/2017 - 08/2012
2	Ascites 01/2013 - 04/2010
2	Infections 10/2010 - 03/2008
2	Adenocarcinoma 04/2010 - 02/2009
2	Medulloblastoma 11/2005 - 02/2005
1	Pregnancy Complications 11/2023
1	Wilms Tumor (Wilm's Tumor) 12/2021
1	Hypertriglyceridemia 11/2021

Drug/Important Bio-Agent (IBA)

24	Cadherins (E-Cadherin)IBA 01/2019 - 05/2007
22	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2018 - 02/2003
13	Epidermal Growth Factor (EGF)IBA 10/2020 - 02/2009
13	His(5)-Trp(7)-Tyr(8)- LHRHIBA 03/2011 - 04/2003
11	Proteins (Proteins, Gene)FDA Link 01/2018 - 12/2003
11	LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)IBA 01/2016 - 07/2002
10	Hormones (Hormone)IBA 01/2016 - 10/2003
9	LigandsIBA 11/2023 - 04/2013
9	ErbB Receptors (EGF Receptor)IBA 05/2019 - 10/2009
8	Messenger RNA (mRNA)IBA 01/2015 - 06/2006
8	GonadotropinsIBA 07/2010 - 04/2003
7	Estrogens (Estrogen)FDA Link 01/2020 - 08/2003
5	Biomarkers (Surrogate Marker)IBA 11/2023 - 01/2010
5	LeptinIBA 11/2021 - 01/2005
5	Estrogen ReceptorsIBA 01/2020 - 12/2004
5	EnzymesIBA 12/2013 - 11/2008
4	Growth Hormone-Releasing Hormone (Somatotropin Releasing Hormone)IBA 01/2022 - 05/2010
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2020 - 05/2016
4	AmphiregulinIBA 05/2019 - 11/2014
4	Small Interfering RNA (siRNA)IBA 01/2017 - 02/2011
4	IntegrinsIBA 01/2017 - 07/2012
4	Estrogen Receptor alphaIBA 11/2013 - 12/2003
4	p38 Mitogen-Activated Protein KinasesIBA 02/2013 - 06/2004
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2012 - 10/2003
4	Mitogen-Activated Protein KinasesIBA 08/2009 - 01/2005
4	SteroidsIBA 03/2008 - 04/2003
3	activin AIBA 01/2021 - 01/2014
3	Connexin 43 (Connexin43)IBA 01/2020 - 10/2015
3	Lithium ChlorideIBA 01/2018 - 03/2011
3	Luteinizing Hormone (Lutropin)FDA LinkGeneric 08/2017 - 06/2005
3	Metalloproteases (Metalloproteinases)IBA 04/2011 - 08/2006
3	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 03/2011 - 04/2006
3	Matrix Metalloproteinases (MMPs)IBA 03/2011 - 11/2006
3	Peptide Hydrolases (Proteases)FDA Link 07/2010 - 04/2006
3	Glycoproteins (Glycoprotein)IBA 01/2010 - 05/2004
2	phenylalanyl- leucyl- phenylalanyl- glutaminyl- prolyl- glutaminyl- arginyl- phenylalaninamideIBA 01/2023 - 01/2020
2	BetacellulinIBA 01/2020 - 05/2016
2	Glucose (Dextrose)FDA LinkGeneric 06/2019 - 02/2017
2	MyostatinIBA 01/2018 - 11/2016
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2018 - 08/2014
2	CytokinesIBA 01/2018 - 02/2007
2	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 04/2017 - 06/2016
2	Insulin-Like PeptidesIBA 02/2017 - 12/2012
2	somatotropin releasing hormone receptorIBA 01/2017 - 05/2010
2	activin BIBA 06/2016 - 10/2015
2	iturelix (Antide)IBA 01/2016 - 03/2006
2	Activins (Activin)IBA 10/2015 - 01/2014
2	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2015 - 05/2015
2	Leptin ReceptorsIBA 03/2013 - 01/2005
2	Indicators and Reagents (Reagents)IBA 02/2013 - 05/2004
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 02/2013 - 08/2010
2	matrigelIBA 08/2011 - 02/2011
2	CollagenIBA 05/2011 - 05/2004
2	ThrombospondinsIBA 04/2011 - 08/2006
2	GelatinIBA 07/2010 - 11/2006
2	Complementary DNA (cDNA)IBA 02/2009 - 09/2007
2	Transcription Factors (Transcription Factor)IBA 03/2008 - 05/2007
2	Progesterone FDA LinkGeneric 03/2008 - 02/2005
2	Progesterone Receptors (Progesterone Receptor)IBA 03/2008 - 08/2003
2	Protein Isoforms (Isoforms)IBA 03/2008 - 11/2006
2	Follicle Stimulating Hormone (Follitropin)FDA Link 04/2006 - 06/2005
2	Protein Kinases (Protein Kinase)IBA 03/2006 - 03/2005
2	FSH Receptors (FSH Receptor)IBA 11/2004 - 05/2002
1	PTX3 proteinIBA 11/2023
1	Bone Morphogenetic Protein 6IBA 11/2023
1	Antineoplastic Agents (Antineoplastics)IBA 01/2022
1	WT1 ProteinsIBA 12/2021
1	UbiquitinIBA 12/2021
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 12/2021
1	LipidsIBA 11/2021

Therapy/Procedure

8	Therapeutics 11/2023 - 06/2004